{"product_id":"tb500-peptides","title":"TB-500","description":"\u003ch2\u003e\u003cb\u003eBuy TB500 Peptides — Synthetic Thymosin β-4\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eTB500 peptides are synthetic preparations of thymosin β-4, a 43-amino-acid actin-binding peptide endogenous to most mammalian cell types and one of the most extensively studied tools in cytoskeletal and tissue-repair research. Researchers across Canada source TB-500 for laboratory work spanning wound healing, angiogenesis, cardiac repair, and cellular migration models.\u003c\/p\u003e\n\u003cp\u003eThe peptide's primary mechanism centers on G-actin sequestration: TB-500 binds monomeric actin and modulates the equilibrium between monomeric and filamentous actin, regulating cell motility, fibroblast organization, and endothelial behavior. Downstream effects observed in published animal and cell studies include keratinocyte migration, capillary network formation, and cardiomyocyte recovery in ischemic injury models.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₂₁₂H₃₅₀N₅₆O₇₈S \/ 4963.44 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 77591-33-4\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes TB-500 a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eThymosin β-4 was first isolated from calf thymic tissue in 1981 by Allan Goldstein and colleagues, with subsequent decades of research expanding its role beyond the immune system to include broad tissue-repair and cytoskeletal-regulation functions. The synthetic 43-amino-acid form, popularized as TB-500 in research and veterinary contexts, became a standard tool for groups studying actin dynamics in vivo.\u003c\/p\u003e\n\u003cp\u003eWhat distinguishes TB-500 from other repair-focused peptides is its mechanistic specificity. By acting as the principal G-actin sequestering peptide, it provides researchers with a defined molecular handle on cytoskeletal organization — a starting point for downstream investigation of cell migration, angiogenic transcriptional programs, and tissue regeneration. Its activity across endothelial, fibroblast, keratinocyte, and cardiomyocyte systems makes it one of the few peptide tools relevant across multiple parallel research domains.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eCellular Migration \u0026amp; Wound Repair —\u003c\/b\u003e Published in vitro and rodent studies report accelerated keratinocyte migration, fibroblast recruitment, and re-epithelialization kinetics in TB-500-treated wound models, with mechanistic work linking effects to G-actin sequestration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAngiogenesis \u0026amp; Vascular Remodeling —\u003c\/b\u003e Animal models have documented increased capillary density and endothelial cell organization in dermal and cardiac tissue, supporting investigation into TB-500's role in vascularization research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCardiac Tissue Models —\u003c\/b\u003e Preclinical studies in murine ischemia-reperfusion models have reported reduced infarct size and improved cardiomyocyte survival, generating sustained interest in TB-500 as a tool peptide for cardiac repair research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSkeletal Muscle \u0026amp; Soft Tissue Repair —\u003c\/b\u003e Published rodent injury models, including muscle crush and tendon laceration designs, describe accelerated recovery markers and improved tissue organization in treated cohorts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAnti-Inflammatory Modulation —\u003c\/b\u003e Cell-based and animal studies have measured reductions in inflammatory cytokine expression and modulation of NF-κB signaling, framing TB-500 as a candidate for investigation into inflammation-coupled tissue repair.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with TB-500 often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-bpc-157\" title=\"View BPC-157 Product Page\"\u003eBPC-157\u003c\/a\u003e\u003c\/b\u003e — Gastric pentadecapeptide studied for nitric-oxide-mediated cytoprotection and VEGFR2-driven angiogenesis; the most common pairing in published soft-tissue repair research, formalized in our Wolvering Stack (see below).\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/ghk-cu\" title=\"View GHK-Cu Product Page\"\u003eGHK-Cu\u003c\/a\u003e\u003c\/b\u003e — Copper tripeptide investigated for ECM remodeling and gene-expression modulation; complements TB-500's cytoskeletal mechanism with a copper-mediated repair angle, and pairs with both compounds in our \u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/glow-peptide-canada\" title=\"View Glow Stack Product Page\"\u003e\u003cstrong\u003eGlow Stack.\u003c\/strong\u003e\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/bpc-157-tb-500-stack\" title=\"View Wolverine Stack Product Page\"\u003eWolverine Stack\u003c\/a\u003e\u003c\/b\u003e — Combined BPC-157 + TB-500 research blend for groups studying repair pathways in parallel.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-retatrutide-canada\" title=\"View Retatrutide Product Page\"\u003e\u003cstrong\u003eRetatrutide (GLP-3)\u003c\/strong\u003e\u003c\/a\u003e \u003cmeta charset=\"utf-8\"\u003e — TB-500's cardiac-research literature complements cardiometabolic designs incorporating Retatrutide.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eIs TB-500 the same as thymosin β-4?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eFunctionally, yes — TB-500 sold as a research peptide is a synthetic version of the full 43-amino-acid thymosin β-4 sequence. The TB-500 designation originated in veterinary and research contexts, while \"thymosin β-4\" is the original biochemical name. Note that some suppliers sell a much shorter 7-amino-acid fragment (Ac-LKKTETQ) under the TB-500 name; ours is the full 43-aa peptide.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is TB-500 different from BPC-157?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are studied in tissue repair contexts but engage different mechanisms. TB-500 acts on the actin cytoskeleton via G-actin sequestration, regulating cell migration and angiogenesis. BPC-157 is a 15-amino-acid pentadecapeptide derived from gastric BPC, with mechanistic work focused on nitric oxide signaling and VEGFR2-mediated vascular remodeling. Many research designs use them together to model complementary repair pathways.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhat is the evidence base for TB-500?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe thymosin β-4 literature spans more than four decades, with hundreds of cell-based and animal studies across wound healing, cardiac repair, neural regeneration, and inflammation models. Mechanistic studies have characterized actin-binding kinetics and downstream signaling. Clinical-stage human data remain limited; the bulk of evidence sits in rodent, large-animal, and cell-system research.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️ \u003cem\u003eFor research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":45745396842633,"sku":null,"price":89.99,"currency_code":"CAD","in_stock":true},{"title":"6x10mg","offer_id":45745396875401,"sku":null,"price":479.99,"currency_code":"CAD","in_stock":true},{"title":"10x10mg (one box)","offer_id":45745396908169,"sku":null,"price":649.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/tb-500-10mg-peptide-canada_standardized.png?v=1778370915","url":"https:\/\/emeraldpeptides.ca\/products\/tb500-peptides","provider":"Emerald Peptides","version":"1.0","type":"link"}