{"product_id":"semax","title":"Semax","description":"\u003ch2\u003e\u003cb\u003eSemax — Synthetic ACTH(4-10) Analog\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSemax is a synthetic heptapeptide and a metabolically stabilized analog of ACTH(4-10), engineered with a C-terminal Pro-Gly-Pro extension that confers resistance to proteolytic degradation. Researchers across Canada source Semax — among the more frequently requested CA peptides for nootropic and neuroprotection research — for its documented activity on BDNF\/TrkB signaling, monoaminergic systems, and neuroprotective transcriptional programs in animal models.\u003c\/p\u003e\n\u003cp\u003eThe peptide combines the ACTH(4-7) core sequence (Met-Glu-His-Phe) with a Pro-Gly-Pro motif that extends half-life. Published preclinical work has measured rapid elevation of hippocampal BDNF and TrkB expression following Semax exposure, alongside modulation of cortical nitric oxide production, lipid peroxidation, and serotonergic and dopaminergic activity.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₃₇H₅₁N₉O₁₀S \/ 813.92 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 80714-61-0\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes Semax a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSemax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences — the same institute that produced its sister compound Selank — and is approved for human clinical use in Russia for ischemic stroke, optic nerve disorders, and post-stroke neurorehabilitation. That clinical track gives Semax a published human dataset that few regulatory peptides circulating in Western research markets can match.\u003c\/p\u003e\n\u003cp\u003eStructurally, Semax retains the ACTH(4-7) tetrapeptide core but deliberately omits the Arg-Trp-Gly residues that would otherwise confer melanocortin receptor activity. The result is a compound with the neurotrophic and cognitive-modulatory effects of ACTH-derived peptides, decoupled from the pigmentary and steroidogenic activity of native ACTH or melanocortin agonists — making Semax a clean tool for groups studying neurotrophin pathways without confounding melanocortin receptor engagement.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eNootropic \u0026amp; Cognitive Research —\u003c\/b\u003e Rodent studies have measured rapid elevation of hippocampal BDNF and TrkB expression following Semax exposure, alongside improved performance in learning, memory, and attention paradigms — supporting its use as a reference tool in neurotrophin-mediated cognitive research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeuroprotection in Ischemia —\u003c\/b\u003e Published rat models of permanent middle cerebral artery occlusion and global ischemia have reported reduced infarct progression, attenuated cortical nitric oxide overproduction, and modulated immune-response gene expression in Semax-treated cohorts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeurotrophin Pathway Modulation —\u003c\/b\u003e Beyond BDNF, Semax has been examined for effects on NGF expression and TrkA signaling, framing it as a broad-spectrum neurotrophin-pathway research tool.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAnxiolytic \u0026amp; Stress Response —\u003c\/b\u003e Animal models have measured increased open-arm time in elevated plus-maze paradigms and attenuated stress-induced behavioral disruption in Semax-treated rodents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCopper-Binding \u0026amp; Aβ Aggregation —\u003c\/b\u003e Recent biochemical studies have characterized Semax's ability to form stable complexes with copper(II) ions in an albumin-like coordination mode, with downstream effects on copper-induced amyloid-β aggregation in neuronal cell models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with Semax often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/selank\" title=\"View Selank Product Page\"\u003eSelank\u003c\/a\u003e\u003c\/b\u003e — The sister regulatory heptapeptide developed at the same Russian institute; Selank targets GABAergic and immunomodulatory pathways for anxiolytic research, complementing Semax's BDNF-driven cognitive and neuroprotective profile in CNS research designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-bpc-157\" title=\"View BPC-157 Product Page\"\u003eBPC-157\u003c\/a\u003e\u003c\/b\u003e — Pentadecapeptide with documented neuroprotective activity in rodent models of TBI and peripheral nerve injury; pairs with Semax in research designs spanning CNS repair, nerve regeneration, and cytoprotection endpoints.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-tesamorelin-canada\" title=\"View Tesamorelin Product Page\"\u003eTesamorelin\u003c\/a\u003e\u003c\/b\u003e — GHRH analog with published cognitive-aging research data, including effects on brain GABA and myo-inositol ratios; provides a complementary mechanism for groups studying peptide-mediated cognitive function across endocrine and regulatory-peptide axes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\n\u003cb\u003eWhy source Semax from a Canadian peptides su\u003c\/b\u003e\u003cb\u003epplier?\u003c\/b\u003e\n\u003c\/h3\u003e\n\u003cp\u003eSourcing within Canada means shorter cold-chain transit and no cross-border customs interruptions, both of which matter for lyophilized peptides shipped to research labs. Our Semax is supplied with batch-specific certificates of analysis confirming ≥99% HPLC purity and mass-spec identity verification, and vials are filled to approximately 104% of the labeled 10 mg as a quality margin for residual losses during reconstitution.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is Semax different from Selank?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are synthetic heptapeptide regulatory peptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, but they target different research domains. Semax is an ACTH(4-10) analog studied primarily for nootropic, neuroprotective, and BDNF-modulating effects in cognitive and ischemic-injury research. Selank is a tuftsin analog studied primarily for anxiolytic and immunomodulatory effects via GABAergic and enkephalin-stabilization pathways. Many research designs use them in parallel to address cognitive and neuro-immune endpoints simultaneously.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs Semax naturally occurring?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. Semax is fully synthetic. Its core sequence corresponds to amino acids 4–7 of the endogenous adrenocorticotropic hormone (ACTH), but the full Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide does not occur in nature — the C-terminal Pro-Gly-Pro extension is engineered to confer metabolic stability beyond what native ACTH fragments achieve.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow does Semax differ from native ACTH or melanocortin agonists?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNative ACTH(4-10) contains the Arg-Trp-Gly motif required for melanocortin receptor activation. Semax deliberately omits these residues, retaining only the ACTH(4-7) core plus the Pro-Gly-Pro extension. This produces a compound with neurotrophic and cognitive activity independent of melanocortin receptor engagement, distinguishing it cleanly from peptides like Melanotan 2 or PT-141.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️\u003cem\u003e For research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":45745418371209,"sku":null,"price":64.99,"currency_code":"CAD","in_stock":true},{"title":"6 x 10mg","offer_id":45745418403977,"sku":null,"price":329.99,"currency_code":"CAD","in_stock":true},{"title":"10 x 10mg (one box)","offer_id":45745418436745,"sku":null,"price":429.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/semax-10mg-peptide-canada_standardized.png?v=1778370681","url":"https:\/\/emeraldpeptides.ca\/products\/semax","provider":"Emerald Peptides","version":"1.0","type":"link"}