{"product_id":"nad-plus","title":"NAD+","description":"\u003ch2\u003e\u003cb\u003eNAD+ – \u003cmeta charset=\"utf-8\"\u003eβ-Nicotinamide Adenine Dinucleotide\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBuy NAD+ in Canada as a research-grade β-nicotinamide adenine dinucleotide for cellular bioenergetics, sirtuin biology, DNA damage response, and mitochondrial research designs. NAD+ is a pyridine dinucleotide coenzyme that operates as both an electron acceptor in cellular respiration and a substrate for sirtuin deacetylases, PARP enzymes, and CD38. Tissue NAD+ levels decline progressively with age, making the compound central to aging research and the broader field of cellular bioenergetics. Each vial supplied by Emerald Peptides ships at ≥99% HPLC purity with mass-spec-verified identity, batch-specific certificate of analysis, and fast domestic Canadian shipping.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized free acid\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 600 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light; long-term storage at −20 °C\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₂₁H₂₇N₇O₁₄P₂ \/ 663.43 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 53-84-9\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes NAD+ a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eNAD+ was first identified in 1906 by Arthur Harden and William Young as a low-molecular-weight cofactor in boiled yeast extracts, and was subsequently linked to pellagra prevention through niacin metabolism by Conrad Elvehjem in 1937. The molecule's structural simplicity — two nucleotides linked through their phosphate groups — masks an extraordinary biological reach: NAD+ participates in hundreds of enzymatic reactions across all known living cells.\u003c\/p\u003e\n\u003cp\u003eWhat distinguishes NAD+ in current research is its dual identity as both a redox cofactor and a consumed substrate. The redox cycling between NAD+ and NADH supports oxidative phosphorylation and ATP synthesis. Separately, NAD+ is consumed by sirtuin deacetylases, PARP enzymes during DNA damage response, and CD38 during cyclic ADP-ribose signaling. This consumption-versus-recycling distinction is central to the modern NAD+ literature — researchers studying age-related NAD+ decline focus on the balance between salvage-pathway synthesis and consuming-enzyme demand. Research groups examining mitochondrial dysfunction, metabolic syndrome, and aging frequently use NAD+ as a tool compound to probe sirtuin-pathway biology and bioenergetic regulation.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eMitochondrial Bioenergetics —\u003c\/b\u003e NAD+ serves as the primary electron acceptor in glycolysis, the TCA cycle, and fatty acid oxidation, making it a foundational tool compound in studies of cellular energy metabolism and mitochondrial function across in vitro and in vivo models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSirtuin Pathway Activation —\u003c\/b\u003e Sirtuins (SIRT1–SIRT7) consume NAD+ to deacetylate histone and non-histone protein substrates, and NAD+ availability is the rate-limiting input for sirtuin activity. Published research has used NAD+ to probe sirtuin-mediated regulation of metabolic, longevity, and stress-response pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDNA Damage Response \u0026amp; PARP Activity —\u003c\/b\u003e Poly(ADP-ribose) polymerases consume large quantities of NAD+ during DNA damage response signaling. Research groups studying genotoxic stress, chemotherapy response, and aging-associated DNA damage frequently incorporate NAD+ as a substrate in cell-based and animal designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAging \u0026amp; Longevity —\u003c\/b\u003e Published human and animal data document age-associated declines in tissue NAD+ levels, with replenishment strategies in rodent models linked to improvements in mitochondrial function, insulin sensitivity, and physical performance markers in aged cohorts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMetabolic \u0026amp; Cardiometabolic Models —\u003c\/b\u003e NAD+ supplementation in rodent models of obesity, insulin resistance, and NAFLD has been examined for effects on glucose homeostasis, hepatic lipid handling, and inflammatory markers, generating sustained interest in NAD+ as a research tool for cardiometabolic-pathway investigation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with NAD+ often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View MOTS-c Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/buy-mots-c-canada\"\u003eMOTS-c\u003c\/a\u003e\u003c\/b\u003e — Mitochondria-derived peptide studied for insulin sensitivity and exercise-mimetic activity; frequently co-investigated with NAD+ in mitochondrial health and metabolic research.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-retatrutide-canada\" title=\"View Retatrutide Product Page\"\u003e\u003cstrong\u003eRetatrutide (GLP-3)\u003c\/strong\u003e\u003c\/a\u003e \u003cmeta charset=\"utf-8\"\u003e— Cardiometabolic research designs increasingly pair NAD+ with incretin-class compounds like Retaturide.\u003cmeta charset=\"utf-8\"\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View SS-31 Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/buy-ss-31\"\u003eSS-31\u003c\/a\u003e\u003c\/b\u003e — Mitochondria-targeted antioxidant peptide studied for cardioprotection and mitochondrial membrane stabilization; co-formulated with NAD+ and MOTS-c in the Mito Stack.\u003cb\u003e\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View Mito Stack Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/mots-c-ss31-nad-stack\"\u003eMito Stack\u003c\/a\u003e\u003c\/b\u003e — Combined MOTS-c + SS-31 + NAD+ research blend for groups studying mitochondrial function across signaling, structural, and cofactor mechanisms in parallel.\u003cmeta charset=\"utf-8\"\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eWhy are we considered among the best places to buy peptides Canada — including NAD+?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eResearchers source from us for three reasons: every batch is HPLC-tested to ≥99% purity with MS-verified identity, every vial ships with a batch-specific certificate of analysis, and orders dispatch from within Canada to avoid border-related cold-chain interruptions. NAD+ vials are filled to approximately 104% of the labeled 600 mg as a quality margin for residual losses during reconstitution.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs NAD+ a peptide?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. NAD+ is a pyridine dinucleotide coenzyme — two nucleotides linked through their phosphate groups, with one bearing a nicotinamide base and the other an adenine base. It is not a peptide and is not assembled from amino acids. It is catalogued alongside research peptides because of its significant overlap with peptide research in mitochondrial, metabolic, and longevity work, and because suppliers serving those research domains typically carry both classes of compound.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow does NAD+ differ from NMN or NR?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNAD+ is the active coenzyme used directly in cellular reactions. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors that cells convert into NAD+ through the salvage pathway. Research designs use the precursors when targeting endogenous synthesis pathways and use NAD+ directly when probing redox biology, sirtuin substrate kinetics, or PARP-pathway research.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhat is the evidence base for NAD+ research?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe NAD+ literature spans more than a century, beginning with Harden and Young's 1906 yeast extract work. Modern interest accelerated after sirtuin biology was characterized in the 2000s and after Imai, Sinclair, and others linked NAD+ decline to age-related metabolic dysfunction. Published research now spans biochemistry, mitochondrial bioenergetics, longevity, neurodegeneration, cardiometabolic, and DNA damage response domains across cell, animal, and human study designs.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️ \u003cem\u003eFor research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"600mg","offer_id":46211766681737,"sku":null,"price":109.99,"currency_code":"CAD","in_stock":true},{"title":"6 x 600mg","offer_id":46211766714505,"sku":null,"price":599.0,"currency_code":"CAD","in_stock":true},{"title":"10 x 600mg (one box)","offer_id":46211766747273,"sku":null,"price":849.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/nad_-600mg-peptide-canada_standardized.png?v=1778370424","url":"https:\/\/emeraldpeptides.ca\/products\/nad-plus","provider":"Emerald Peptides","version":"1.0","type":"link"}