{"product_id":"mots-c-ss31-nad-stack","title":"Mito Stack (MOTS-c + SS-31 + NAD+)","description":"\u003ch2\u003e\u003cb\u003eMOTS-c SS-31 NAD+ Stack — The Mito Stack Blend\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eThe MOTS-c SS-31 NAD+ stack — known as the Mito Stack — pairs three of the most studied compounds in mitochondrial biology into a single research kit. Canadian research labs source this mitochondrial peptide stack for laboratory work in bioenergetics, longevity, and mitochondrial-dysfunction research designs that benefit from parallel investigation of signaling, structural, and cofactor mechanisms.\u003c\/p\u003e\n\u003cp\u003eThe three compounds engage entirely different aspects of mitochondrial biology. MOTS-c is a 16-amino-acid mitochondria-derived peptide encoded within mtDNA that activates AMPK and acts as a mitochondrial-nuclear retrograde signal. SS-31 is a synthetic Szeto-Schiller tetrapeptide that binds cardiolipin on the inner mitochondrial membrane to stabilize cristae structure. NAD+ is the pyridine dinucleotide coenzyme central to redox cycling, sirtuin-pathway signaling, and bioenergetic flux.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Three lyophilized compounds, supplied as a kit\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per kit:\u003c\/b\u003e 10 mg MOTS-c + 10 mg SS-31 + 600 mg NAD+ (each filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified, all components)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified per COA (all components)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light; long-term NAD+ storage at −20 °C\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eComponents:\u003c\/b\u003e See individual product pages for full sequence, formula, MW, and CAS data\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes the Mito Stack a Unique Combination\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eThe MOTS-c SS-31 NAD+ stack reflects a deliberate stratification across the three principal layers of mitochondrial biology that researchers commonly investigate. MOTS-c addresses the signaling layer — communicating bioenergetic status from mitochondria to the nucleus and activating AMPK as a master energy-sensing kinase. SS-31 addresses the structural layer — binding cardiolipin on the inner mitochondrial membrane and stabilizing cristae morphology in compromised mitochondria. NAD+ addresses the biochemical layer — cycling between oxidized and reduced forms in redox reactions and serving as a consumed substrate for sirtuins, PARPs, and CD38.\u003c\/p\u003e\n\u003cp\u003eThis three-layer separation gives research groups clean mechanistic resolution. Rather than three compounds with overlapping modes of action, each operates at a distinct level of mitochondrial biology, allowing experimental designs to probe signaling, structural, and cofactor contributions in the same model system. The combination matches the modern mitochondrial-research literature, where studies frequently address all three layers simultaneously to characterize bioenergetic phenotypes in aging, metabolic, and cardiac models. As a longevity peptide stack Canada-shipped from a single supply point with matched batch documentation, the Mito Stack simplifies the documentation chain for laboratories operating under quality-control protocols.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eThree-Layer Mitochondrial Investigation —\u003c\/b\u003e The combination allows research designs to address signaling (MOTS-c \/ AMPK), structural (SS-31 \/ cardiolipin), and biochemical (NAD+ \/ redox and sirtuin) mechanisms simultaneously, with each compound serving a distinct role in the same model system.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAging \u0026amp; Longevity Research —\u003c\/b\u003e All three compounds connect to age-associated mitochondrial decline. MOTS-c plasma levels decline with age in published human and animal data. SS-31 has been studied in aged-rodent skeletal muscle and cardiac models. NAD+ tissue levels decline progressively with age. Combined research designs build on three independent literatures within longevity research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCardiac Bioenergetics —\u003c\/b\u003e Rodent ischemia-reperfusion models have separately characterized SS-31's effects on infarct size and mitochondrial respiration. NAD+ has been examined in heart failure and cardiometabolic models. MOTS-c has been studied for metabolic effects relevant to cardiac substrate handling. The stack supports research designs combining all three.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eInsulin Sensitivity \u0026amp; Metabolic Models —\u003c\/b\u003e MOTS-c activates AMPK to improve skeletal muscle glucose uptake. SS-31 has been characterized in type 2 diabetes models for effects on oxidative stress and ER stress. NAD+ has documented effects in rodent obesity and NAFLD models. The combination addresses metabolic dysfunction from three angles.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eReactive Oxygen Species \u0026amp; Redox Biology —\u003c\/b\u003e SS-31 reduces mitochondrial ROS production via cardiolipin binding. NAD+ governs cellular redox state through NAD+\/NADH cycling. MOTS-c has been characterized for effects on antioxidant pathways through AMPK-mediated transcription. Combined research designs cover redox biology across structural and biochemical layers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with the Mito Stack often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-mots-c-canada\" title=\"View MOTS-c Product Page\"\u003eMOTS-c\u003c\/a\u003e\u003c\/b\u003e — Available as a single-compound vial for research designs requiring MOTS-c alone or at non-stack ratios.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-ss-31\" title=\"View SS-31 Product Page\"\u003eSS-31\u003c\/a\u003e\u003c\/b\u003e — Available as a single-compound vial for research designs requiring SS-31 alone or at non-stack ratios.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/nad-plus\" title=\"View NAD+ Product Page\"\u003eNAD+\u003c\/a\u003e\u003c\/b\u003e — Available as a single-compound vial for research designs requiring NAD+ alone or at non-stack ratios.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eWhere can researchers buy the MOTS-c SS-31 NAD+ stack in Canada with verified purity?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eOur Mito Stack ships to Canadian research labs and independent investigators with three batch-specific certificates of analysis — one per component — confirming ≥99% HPLC purity and mass-spec identity verification for MOTS-c, SS-31, and NAD+. Each vial is filled to approximately 104% of label as a quality margin for residual losses during reconstitution work, and orders dispatch from within Canada to avoid border-related cold-chain interruptions.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow are MOTS-c, SS-31, and NAD+ different from each other mechanistically?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eMOTS-c is a 16-amino-acid mitochondria-derived peptide that activates AMPK and acts as a signaling molecule between mitochondria and the nucleus — a regulatory mechanism. SS-31 is a synthetic tetrapeptide that binds cardiolipin on the inner mitochondrial membrane to stabilize cristae structure and reduce ROS production — a structural mechanism. NAD+ is a pyridine dinucleotide coenzyme that participates in redox cycling and serves as a consumed substrate for sirtuins, PARPs, and CD38 — a biochemical mechanism. The three compounds operate at different levels of mitochondrial biology.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhy combine these three compounds in a single research kit?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe combination matches how mitochondrial-research designs are typically structured. Studies of mitochondrial dysfunction in aging, cardiac disease, metabolic syndrome, and neurodegeneration often address signaling, structural, and biochemical layers simultaneously — because dysfunction at one layer typically propagates to the others. A single kit gives research groups all three reference compounds with matched batch documentation, simplifying experimental designs that probe parallel mechanisms.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs NAD+ a peptide?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. NAD+ is a pyridine dinucleotide coenzyme — two nucleotides linked through their phosphate groups, not assembled from amino acids. It is included in the Mito Stack and catalogued alongside research peptides because of its central role in mitochondrial bioenergetics and its frequent appearance in research designs alongside MOTS-c and SS-31. Many suppliers serving the mitochondrial research domain carry both peptide and non-peptide compounds in this category.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️ \u003cem\u003eFor research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg\/10mg\/600mg (one vial)","offer_id":46211113713801,"sku":null,"price":164.99,"currency_code":"CAD","in_stock":false},{"title":"6 x 10mg\/10mg\/600mg","offer_id":46211113746569,"sku":null,"price":899.99,"currency_code":"CAD","in_stock":false},{"title":"10 x 10mg\/10mg\/600mg (one box)","offer_id":46211113779337,"sku":null,"price":1369.99,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/mots-c-ss-31-nad_-mito-stack-peptide-canada_standardized_7a60a455-0cdf-4180-aa0a-b728c3f5e20c.png?v=1778371936","url":"https:\/\/emeraldpeptides.ca\/products\/mots-c-ss31-nad-stack","provider":"Emerald Peptides","version":"1.0","type":"link"}