{"product_id":"buy-ss-31","title":"SS-31","description":"\u003ch2\u003e\u003cb\u003eBuy SS-31 Canada — Mitochondria-Targeted Tetrapeptide\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSS-31 is a synthetic aromatic-cationic tetrapeptide and a member of the Szeto-Schiller (SS) peptide family — a class of mitochondria-targeted compounds engineered to selectively concentrate within the inner mitochondrial membrane. Researchers across Canada looking to buy SS-31 source the compound for laboratory work in mitochondrial bioenergetics, cardiolipin biology, oxidative stress, and cardiac and renal ischemia-reperfusion research.\u003c\/p\u003e\n\u003cp\u003eThe peptide binds cardiolipin — a phospholipid found exclusively on the inner mitochondrial membrane — with high selectivity, concentrating more than 1,000-fold in mitochondria relative to surrounding cytoplasm. Published preclinical work has documented downstream effects on electron transport chain efficiency, cristae structure, reactive oxygen species production, and ATP synthesis across cardiac, renal, skeletal muscle, and neural tissue models.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₃₂H₄₉N₉O₅ \/ 639.8 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 736992-21-5\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes SS-31 a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSS-31 was developed in the early 2000s by Hazel Szeto and Peter Schiller as part of a research program at Cornell University and the Clinical Research Institute of Montreal aimed at producing cell-permeable peptide antioxidants. The Szeto-Schiller series introduced an alternating aromatic-cationic motif that allowed the peptides to cross plasma and mitochondrial membranes without requiring active transport — a defining property that distinguishes them from earlier mitochondrial-targeted compounds.\u003c\/p\u003e\n\u003cp\u003eWhat sets SS-31 apart from other mitochondrial research tools is its mechanism of localization. Unlike triphenylphosphonium-based mitochondrial targeting strategies that rely on membrane potential, SS-31 binds cardiolipin directly and concentrates in the inner mitochondrial membrane independent of bioenergetic state. This makes it a reliable tool in research models where mitochondrial membrane potential is compromised — including ischemia-reperfusion, heart failure, and tafazzin-deficient cardiolipin-remodeling systems where conventional mitochondrial probes fail.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eCardiolipin Stabilization \u0026amp; Cristae Structure —\u003c\/b\u003e Published cell and animal studies have measured SS-31-driven preservation of cristae morphology and cardiolipin content in mitochondrial dysfunction models, with mechanistic work pointing to direct cardiolipin binding via the peptide's aromatic-cationic motif.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eReactive Oxygen Species Reduction —\u003c\/b\u003e SS-31 inhibits cardiolipin peroxidation and reduces mitochondrial ROS production in oxidative stress models, supporting its use as a reference tool in research designs probing redox-balance and antioxidant pathway biology.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCardiac Ischemia-Reperfusion —\u003c\/b\u003e Preclinical work in rodent cardiac IR injury has reported reduced infarct size and preserved mitochondrial respiration in SS-31-treated cohorts, making the peptide a frequently cited tool in cardiac bioenergetics research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSkeletal Muscle Bioenergetics —\u003c\/b\u003e Aged-rodent studies have measured improvements in skeletal muscle ATP production, exercise tolerance, and fatigue resistance following SS-31 exposure, generating sustained interest in the peptide for mitochondrial-myopathy and aging-muscle research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eRenal \u0026amp; Neural Mitochondrial Research —\u003c\/b\u003e Published animal models of renal ischemia, atherosclerotic renal artery stenosis, and neurodegeneration have characterized SS-31's effects on mitochondrial function in non-cardiac tissue, expanding its utility as a tool compound across multiple research domains.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with SS-31 often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-retatrutide-canada\" title=\"View Retatrutide Product Page\"\u003e\u003cstrong\u003eRetatrutide (GLP-3)\u003c\/strong\u003e\u003c\/a\u003e \u003cmeta charset=\"utf-8\"\u003e — SS-31's documented T2D research overlaps with the glycemic-endpoint literature for Retatrutide.\u003cb\u003e\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-mots-c-canada\" title=\"View MOTS-c Product Page\"\u003eMOTS-c\u003c\/a\u003e\u003c\/b\u003e — Mitochondria-derived signaling peptide that activates AMPK; complements SS-31's structural cardiolipin-stabilization mechanism with a signaling-pathway angle, and pairs with both compounds in our Mito Stack (see below). \u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"file:\/\/\/products\/nad\" title=\"View NAD+ Product Page\"\u003eNAD+\u003c\/a\u003e\u003c\/b\u003e — Mitochondrial cofactor central to sirtuin signaling and redox balance; the third compound in the Mito Stack and a frequent companion in bioenergetics research designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/mots-c-ss31-nad-stack\" title=\"View Mito Stack Product Page\"\u003eMito Stack\u003c\/a\u003e\u003c\/b\u003e — Combined MOTS-c + SS-31 + NAD+ research blend for groups studying mitochondrial function across signaling, structural, and cofactor mechanisms in parallel.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eWhere can I buy SS-31 in Canada with verified purity?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eOur SS-31 ships to Canadian research labs and independent investigators with a batch-specific certificate of analysis confirming ≥99% HPLC purity and mass-spec identity verification. Vials are filled to approximately 104% of the labeled 10 mg as a quality margin for residual losses during reconstitution work, and ship from within Canada to avoid border-related cold-chain interruptions.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is SS-31 different from MOTS-c?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are mitochondria-focused peptides but engage entirely different mechanisms. SS-31 is a synthetic tetrapeptide that binds cardiolipin on the inner mitochondrial membrane to stabilize cristae structure and reduce ROS production — a structural mechanism. MOTS-c is a 16-amino-acid mitochondria-derived peptide that activates AMPK and acts as a mitochondrial-nuclear retrograde signal — a signaling mechanism. Many research designs use them together to address mitochondrial function from both structural and signaling angles.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs SS-31 naturally occurring?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. SS-31 is fully synthetic, designed by Szeto and Schiller as part of a structure-activity program targeting mitochondrial peptide antioxidants. The aromatic-cationic motif and the inclusion of D-arginine and 2',6'-dimethyltyrosine are deliberately non-natural, conferring both protease resistance and the cardiolipin-binding selectivity that defines the compound.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhat is the evidence base for SS-31?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe published preclinical literature spans more than two decades and covers cardiac ischemia-reperfusion, heart failure, mitochondrial myopathy, renal ischemia, neurodegeneration, type 2 diabetes, and aging-related muscle dysfunction across cell, rodent, and large-animal models. Clinical trials have been conducted under the development codes elamipretide and MTP-131 in cardiomyopathy, mitochondrial myopathy, and Barth syndrome populations, providing a substantial human pharmacokinetic and safety dataset.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️ \u003cem\u003eFor research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":46211938615433,"sku":null,"price":59.99,"currency_code":"CAD","in_stock":true},{"title":"6 x 10mg","offer_id":46211938648201,"sku":null,"price":329.99,"currency_code":"CAD","in_stock":true},{"title":"10 x 10mg (one box)","offer_id":46211938680969,"sku":null,"price":489.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/ss-31-10mg-peptide-canada_standardized_dba7d997-92cc-4750-a55f-9f8f9fa5f3f2.png?v=1778372064","url":"https:\/\/emeraldpeptides.ca\/products\/buy-ss-31","provider":"Emerald Peptides","version":"1.0","type":"link"}