{"product_id":"buy-melanotan-2-canada","title":"Melanotan II (MT-2)","description":"\u003ch2\u003e\u003cb\u003eBuy Melanotan 2 Canada — Synthetic α-MSH Analog\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMelanotan 2 is a synthetic cyclic heptapeptide and a non-selective agonist of the melanocortin receptor family, originally engineered as a metabolically stable analog of α-melanocyte-stimulating hormone (α-MSH). Canadian research labs looking to buy Melanotan 2 (often abbreviated MT-2 or Melanotan II) source the compound for laboratory work in pigmentation, melanocortin receptor signaling, and energy-balance research.\u003c\/p\u003e\n\u003cp\u003eThe peptide engages MC1R, MC3R, MC4R, and MC5R, giving research groups a single tool to probe multiple receptor-linked phenotypes — melanogenesis, appetite regulation, sexual response circuitry, and sebaceous gland behavior. Its cyclic lactam structure and non-natural amino acid substitutions confer the metabolic stability that linear α-MSH lacks.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₅₀H₆₉N₁₅O₉ \/ 1024.18 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 121062-08-6\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes Melanotan 2 a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eMelanotan 2 was developed at the University of Arizona by Victor Hruby and colleagues in the late 1980s as part of a structure-activity program designed to produce metabolically stable α-MSH analogs. The key innovations — replacement of methionine with norleucine, substitution of L-phenylalanine with its D-enantiomer, and lactamization between aspartic acid and lysine to lock the peptide into its bioactive conformation — produced a compound with substantially extended half-life and full agonist activity at multiple melanocortin receptors.\u003c\/p\u003e\n\u003cp\u003eWhat distinguishes Melanotan 2 from later melanocortin tools is its broad receptor profile. Where bremelanotide (PT-141) shows preferential activity at MC4R, Melanotan 2 acts as a non-selective agonist across MC1R, MC3R, MC4R, and MC5R — making it a useful reference compound for groups dissecting receptor-specific contributions to melanocortin pathway phenotypes.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003ePigmentation \u0026amp; Melanogenesis —\u003c\/b\u003e MC1R activation in melanocyte models drives eumelanin synthesis through cAMP-PKA-MITF signaling. Published cell and animal studies have measured dose-dependent increases in melanin content following Melanotan 2 exposure, supporting its use as a reference tool in pigmentation research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAppetite \u0026amp; Energy Balance —\u003c\/b\u003e Hypothalamic MC3R and MC4R activation has been studied for its role in feeding suppression. Rodent models have reported reduced food intake across multiple hyperphagia paradigms following intracerebroventricular Melanotan 2 administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMelanocortin Receptor Pharmacology —\u003c\/b\u003e As a non-selective full agonist, Melanotan 2 serves as a baseline tool compound in receptor-deconvolution studies where researchers compare its profile against subtype-selective agonists and antagonists.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eUV Photoprotection Research —\u003c\/b\u003e Eumelanin produced via MC1R activation absorbs UV radiation, and Melanotan 2 has been investigated in animal models as a tool for studying tan-mediated photoprotection independent of UV exposure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSexual Response Circuitry —\u003c\/b\u003e MC3R\/MC4R activation in CNS pathways has been examined in animal models of sexual response, with Melanotan 2 preceding the development of more receptor-selective compounds in this research area.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with Melanotan 2 often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/pt-141\" title=\"View PT-141 Product Page\"\u003ePT-141\u003c\/a\u003e\u003c\/b\u003e — Bremelanotide, an MC3R\/MC4R-preferring melanocortin agonist; the standard mechanistic contrast for Melanotan 2 in receptor-selectivity studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/ghk-cu\" title=\"View GHK-Cu Product Page\"\u003eGHK-Cu\u003c\/a\u003e\u003c\/b\u003e — Copper tripeptide investigated for ECM remodeling and skin biology; complements Melanotan 2's pigmentation focus with a separate copper-mediated dermal-research angle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"file:\/\/\/products\/buy-bpc-157\" title=\"View BPC-157 Product Page\"\u003eBPC-157\u003c\/a\u003e\u003c\/b\u003e — Pentadecapeptide studied for cytoprotection and tissue repair; pairs with Melanotan 2 in dermal-research designs spanning pigmentation and repair endpoints.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eWhere can researchers buy Melanotan 2 in Canada with verified purity?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eOur Melanotan 2 ships to Canadian research labs and independent investigators with a batch-specific certificate of analysis confirming ≥99% HPLC purity and mass-spec identity verification. Vials are filled to approximately 104% of the labeled 10 mg as a quality margin for residual losses during reconstitution work, and ship from within Canada to avoid border-related cold-chain interruptions.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is Melanotan 2 different from PT-141?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are α-MSH-derived melanocortin agonists, but they differ in receptor selectivity. Melanotan 2 is a non-selective full agonist across MC1R, MC3R, MC4R, and MC5R, making it active in pigmentation, appetite, and sexual-response research. PT-141 (bremelanotide) shows preferential activity at MC3R and MC4R, with reduced MC1R engagement, which is why it became the focus of CNS-mediated sexual response research while Melanotan 2 remained a broader pigmentation and melanocortin-pathway tool.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs Melanotan 2 naturally occurring?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. Melanotan 2 is a synthetic cyclic heptapeptide engineered as a stable analog of α-MSH, the natural melanocortin hormone that consists of a 13-amino-acid linear sequence. The structural modifications — D-phenylalanine substitution, norleucine for methionine, and the Asp-Lys lactam bridge — are deliberately non-natural and confer the metabolic stability that endogenous α-MSH lacks.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhat is the evidence base for Melanotan 2?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe published preclinical literature spans more than three decades, beginning with foundational structure-activity work from Hruby and colleagues at the University of Arizona in the late 1980s and 1990s. Subsequent cell and animal studies have characterized melanogenesis, appetite, and CNS effects across multiple model systems. Pilot human clinical data exist but Melanotan 2 has not received approval from any major regulatory agency for human use.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️\u003cem\u003e For research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":45745407656073,"sku":null,"price":44.99,"currency_code":"CAD","in_stock":true},{"title":"6 x 10mg","offer_id":45745407688841,"sku":null,"price":259.99,"currency_code":"CAD","in_stock":true},{"title":"10 x 10mg (one box)","offer_id":45745407721609,"sku":null,"price":399.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/melanotan-II-MT-2-10mg-peptide-canada_standardized_147a9c06-3f6e-4f61-ae0d-378bf259f4fc.png?v=1778370884","url":"https:\/\/emeraldpeptides.ca\/products\/buy-melanotan-2-canada","provider":"Emerald Peptides","version":"1.0","type":"link"}