{"title":"Cognitive \u0026 Nootropic","description":"\u003cp class=\"font-claude-response-body\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003eThis collection brings together the best peptides for cognitive function research in our Canadian catalog — synthetic regulatory peptides with documented activity across BDNF\/NGF signaling, neuroprotection, GABAergic transmission, and immunomodulatory pathways.\u003c\/span\u003e\u003c\/p\u003e","products":[{"product_id":"semax","title":"Semax","description":"\u003ch2\u003e\u003cb\u003eSemax — Synthetic ACTH(4-10) Analog\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cmeta charset=\"utf-8\"\u003eBuy Semax in Canada as a research-grade synthetic peptide for nootropic, neuroprotective, and BDNF-modulation research designs. Semax is a synthetic heptapeptide analog of ACTH(4-10), originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and approved for clinical use in Russia and Ukraine for ischemic stroke and post-stroke neurorehabilitation. Each vial supplied by Emerald Peptides ships at ≥99% HPLC purity with mass-spec-verified identity, batch-specific certificate of analysis, and fast domestic Canadian shipping.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₃₇H₅₁N₉O₁₀S \/ 813.92 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 80714-61-0\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes Semax a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSemax was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences — the same institute that produced its sister compound Selank — and is approved for human clinical use in Russia for ischemic stroke, optic nerve disorders, and post-stroke neurorehabilitation. That clinical track gives Semax a published human dataset that few regulatory peptides circulating in Western research markets can match.\u003c\/p\u003e\n\u003cp\u003eStructurally, Semax retains the ACTH(4-7) tetrapeptide core but deliberately omits the Arg-Trp-Gly residues that would otherwise confer melanocortin receptor activity. The result is a compound with the neurotrophic and cognitive-modulatory effects of ACTH-derived peptides, decoupled from the pigmentary and steroidogenic activity of native ACTH or melanocortin agonists — making Semax a clean tool for groups studying neurotrophin pathways without confounding melanocortin receptor engagement.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eNootropic \u0026amp; Cognitive Research —\u003c\/b\u003e Rodent studies have measured rapid elevation of hippocampal BDNF and TrkB expression following Semax exposure, alongside improved performance in learning, memory, and attention paradigms — supporting its use as a reference tool in neurotrophin-mediated cognitive research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeuroprotection in Ischemia —\u003c\/b\u003e Published rat models of permanent middle cerebral artery occlusion and global ischemia have reported reduced infarct progression, attenuated cortical nitric oxide overproduction, and modulated immune-response gene expression in Semax-treated cohorts.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeurotrophin Pathway Modulation —\u003c\/b\u003e Beyond BDNF, Semax has been examined for effects on NGF expression and TrkA signaling, framing it as a broad-spectrum neurotrophin-pathway research tool.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAnxiolytic \u0026amp; Stress Response —\u003c\/b\u003e Animal models have measured increased open-arm time in elevated plus-maze paradigms and attenuated stress-induced behavioral disruption in Semax-treated rodents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCopper-Binding \u0026amp; Aβ Aggregation —\u003c\/b\u003e Recent biochemical studies have characterized Semax's ability to form stable complexes with copper(II) ions in an albumin-like coordination mode, with downstream effects on copper-induced amyloid-β aggregation in neuronal cell models.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with Semax often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View Selank Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/selank\"\u003eSelank\u003c\/a\u003e\u003c\/b\u003e — The sister regulatory heptapeptide developed at the same Russian institute; Selank targets GABAergic and immunomodulatory pathways for anxiolytic research, complementing Semax's BDNF-driven cognitive and neuroprotective profile in CNS research designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View BPC-157 Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/buy-bpc-157\"\u003eBPC-157\u003c\/a\u003e\u003c\/b\u003e — Pentadecapeptide with documented neuroprotective activity in rodent models of TBI and peripheral nerve injury; pairs with Semax in research designs spanning CNS repair, nerve regeneration, and cytoprotection endpoints.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca title=\"View Tesamorelin Product Page\" href=\"https:\/\/emeraldpeptides.ca\/products\/buy-tesamorelin-canada\"\u003eTesamorelin\u003c\/a\u003e\u003c\/b\u003e — GHRH analog with published cognitive-aging research data, including effects on brain GABA and myo-inositol ratios; provides a complementary mechanism for groups studying peptide-mediated cognitive function across endocrine and regulatory-peptide axes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\n\u003cb\u003eWhy source Semax from a Canadian peptides su\u003c\/b\u003e\u003cb\u003epplier?\u003c\/b\u003e\n\u003c\/h3\u003e\n\u003cp\u003eSourcing within Canada means shorter cold-chain transit and no cross-border customs interruptions, both of which matter for lyophilized peptides shipped to research labs. Our Semax is supplied with batch-specific certificates of analysis confirming ≥99% HPLC purity and mass-spec identity verification, and vials are filled to approximately 104% of the labeled 10 mg as a quality margin for residual losses during reconstitution.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is Semax different from Selank?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are synthetic heptapeptide regulatory peptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, but they target different research domains. Semax is an ACTH(4-10) analog studied primarily for nootropic, neuroprotective, and BDNF-modulating effects in cognitive and ischemic-injury research. Selank is a tuftsin analog studied primarily for anxiolytic and immunomodulatory effects via GABAergic and enkephalin-stabilization pathways. Many research designs use them in parallel to address cognitive and neuro-immune endpoints simultaneously.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs Semax naturally occurring?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNo. Semax is fully synthetic. Its core sequence corresponds to amino acids 4–7 of the endogenous adrenocorticotropic hormone (ACTH), but the full Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide does not occur in nature — the C-terminal Pro-Gly-Pro extension is engineered to confer metabolic stability beyond what native ACTH fragments achieve.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow does Semax differ from native ACTH or melanocortin agonists?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eNative ACTH(4-10) contains the Arg-Trp-Gly motif required for melanocortin receptor activation. Semax deliberately omits these residues, retaining only the ACTH(4-7) core plus the Pro-Gly-Pro extension. This produces a compound with neurotrophic and cognitive activity independent of melanocortin receptor engagement, distinguishing it cleanly from peptides like Melanotan 2 or PT-141.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️\u003cem\u003e For research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":45745418371209,"sku":null,"price":64.99,"currency_code":"CAD","in_stock":true},{"title":"6 x 10mg","offer_id":45745418403977,"sku":null,"price":329.99,"currency_code":"CAD","in_stock":true},{"title":"10 x 10mg (one box)","offer_id":45745418436745,"sku":null,"price":429.99,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/semax-10mg-peptide-canada_standardized.png?v=1778370681"},{"product_id":"selank","title":"Selank","description":"\u003ch2\u003e\u003cb\u003eSelank — Synthetic Tuftsin Analog\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eBuy Selank in Canada as a research-grade synthetic peptide for anxiolytic, immunomodulatory, and GABAergic research designs. Selank is a synthetic heptapeptide analog of the endogenous immunomodulator tuftsin, developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and approved for clinical use in Russia and Ukraine for generalized anxiety disorder. Each vial supplied by Emerald Peptides ships at ≥99% HPLC purity with mass-spec-verified identity, batch-specific certificate of analysis, and fast domestic Canadian shipping.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eProduct Details\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eForm:\u003c\/b\u003e Lyophilized peptide\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNet per vial:\u003c\/b\u003e 10 mg (filled to approximately 104% of label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003ePurity:\u003c\/b\u003e ≥99% (HPLC-verified)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eIdentity:\u003c\/b\u003e MS-verified (per COA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStorage:\u003c\/b\u003e 2–8 °C, protect from light\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eFormula \/ M.W.:\u003c\/b\u003e C₃₃H₅₇N₁₁O₉ \/ 751.88 Da\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCAS:\u003c\/b\u003e 129954-34-3\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eWhat Makes Selank a Unique Compound\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eSelank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in collaboration with the V.V. Zakusov Research Institute of Pharmacology, and is approved for human clinical use as an anxiolytic in Russia and Ukraine — a regulatory profile that distinguishes it from most synthetic regulatory peptides circulating in Western research markets. Its parent compound, tuftsin, is a four-amino-acid fragment of the IgG heavy chain Fc region with documented immunomodulatory activity.\u003c\/p\u003e\n\u003cp\u003eThe structural innovation in Selank is the C-terminal Pro-Gly-Pro tripeptide. This extension shields tuftsin from enzymatic cleavage and produces a peptide that retains the parent's immunoregulatory profile while adding well-characterized anxiolytic and cognitive activity. Among research peptides operating at the neuro-immune interface, Selank is one of the few tools with both a developed clinical dataset and a clear mechanistic profile spanning GABAergic, monoaminergic, and enkephalin-pathway endpoints.\u003c\/p\u003e\n\u003ch2\u003e\u003cb\u003eKey Benefits\u003c\/b\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eAnxiolytic \/ GABAergic Modulation —\u003c\/b\u003e Rodent studies have measured increased amplitude and discharge rate of inhibitory postsynaptic currents in hippocampal CA1 neurons following Selank exposure, supporting investigation into GABAergic-mediated anxiety models without the dependence profile associated with benzodiazepine tools.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNootropic \u0026amp; Cognitive Research —\u003c\/b\u003e Published animal models have reported improvements in learning, memory consolidation, and orientational-investigative behavior, with mechanistic work linking effects to BDNF expression and serotonin metabolism modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eImmune \u0026amp; Cytokine Modulation —\u003c\/b\u003e Selank has been characterized in animal studies as a modulator of IL-6 expression and T-helper cell cytokine balance, retaining the immunoregulatory profile of its tuftsin parent compound.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eEnkephalin Stabilization \u0026amp; Opioid Withdrawal Research —\u003c\/b\u003e Preclinical work has examined Selank's inhibition of enkephalin degradation in models of morphine withdrawal, with rat studies measuring attenuation of aversive withdrawal signs following administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eStress Response —\u003c\/b\u003e Animal studies of acute stress have reported reduced affective response and decreased erroneous escape attempts in Selank-treated cohorts, framing the peptide as a research tool for HPA-axis and behavioral stress paradigms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eRelated Peptides\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003eResearchers working with Selank often investigate it alongside:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/semax\" title=\"View Semax Product Page\"\u003eSemax\u003c\/a\u003e\u003c\/b\u003e — The sister regulatory heptapeptide developed at the same Russian institute; Semax targets BDNF\/NGF pathways for cognitive and neuroprotective research, complementing Selank's anxiolytic and immunomodulatory profile in CNS research designs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-bpc-157\" title=\"View BPC-157 Product Page\"\u003eBPC-157\u003c\/a\u003e\u003c\/b\u003e — Pentadecapeptide with documented anxiolytic and gut-brain-axis activity in rodent models; pairs with Selank in research designs probing the intersection of GI biology, stress response, and behavioral endpoints.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003e\u003ca href=\"https:\/\/emeraldpeptides.ca\/products\/buy-tesamorelin-canada\" title=\"View Tesamorelin Product Page\"\u003eTesamorelin\u003c\/a\u003e\u003c\/b\u003e — GHRH analog with published cognitive-aging research data; provides a complementary mechanism for groups studying peptide-mediated cognitive function across endocrine and regulatory-peptide axes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cb\u003eFrequently Asked Questions\u003c\/b\u003e\u003c\/h2\u003e\n\u003ch3\u003e\u003cb\u003eWhy source Selank from a Canadian peptides CA supplier?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eSourcing within Canada means shorter cold-chain transit and no cross-border customs interruptions, both of which matter for lyophilized peptides shipped to research labs. Our Selank is supplied with batch-specific certificates of analysis confirming ≥99% HPLC purity and mass-spec identity verification, and vials are filled to approximately 104% of the labeled 10 mg as a quality margin for residual losses during reconstitution.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eHow is Selank different from Semax?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eBoth are synthetic heptapeptide regulatory peptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, but they target different research domains. Selank is a tuftsin analog studied primarily for anxiolytic and immunomodulatory effects, with documented activity in GABAergic and enkephalin-stabilization research. Semax is an ACTH(4–10) analog studied primarily for BDNF\/NGF-mediated cognitive and neuroprotective research. Many research designs use them in parallel to address neuro-immune and cognitive endpoints simultaneously.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eIs Selank naturally occurring?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eThe parent peptide, tuftsin (Thr-Lys-Pro-Arg), is a naturally occurring tetrapeptide produced from immunoglobulin G heavy chain cleavage. Selank itself, with its C-terminal Pro-Gly-Pro extension, is fully synthetic — the seven-amino-acid sequence does not occur in nature, and the extension was deliberately engineered to extend the metabolic stability of the native tuftsin fragment.\u003c\/p\u003e\n\u003ch3\u003e\u003cb\u003eWhat is the evidence base for Selank?\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp\u003eSelank has been studied extensively in Russian and international preclinical literature since the 1990s, with characterized effects across anxiety, cognition, immune modulation, and opioid-withdrawal models. It is approved for human anxiolytic use in Russia and Ukraine, providing a clinical dataset most regulatory peptides lack. Mechanistic work has implicated GABAergic, serotonergic, BDNF-pathway, and enkephalinase-inhibition contributions.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e⚠️ \u003cem\u003eFor research use only. Not intended for human or veterinary use. Not a drug, food, or supplement.\u003c\/em\u003e\u003c\/p\u003e","brand":"Emerald Peptides","offers":[{"title":"10mg","offer_id":45745419878537,"sku":null,"price":39.99,"currency_code":"CAD","in_stock":false},{"title":"6 x 10mg","offer_id":45745419911305,"sku":null,"price":229.99,"currency_code":"CAD","in_stock":false},{"title":"10 x 10mg (one box)","offer_id":45745419944073,"sku":null,"price":349.99,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0760\/3424\/4745\/files\/selank-10mg-peptide-canada_standardized.png?v=1778369123"}],"url":"https:\/\/emeraldpeptides.ca\/collections\/best-peptides-for-cognitive-function.oembed","provider":"Emerald Peptides","version":"1.0","type":"link"}